Assessment of Two Commonly used Dermal Regeneration Templates in a Swine Model without Skin Grafting

In the medical care of partial and full-thickness wounds, autologous skin grafting is still gold standard dermal replacement. contrast to spontaneous reepithelializing superficial deep wounds often lead disturbing scarring, with cosmetically or functionally unsatisfactory results. However, modern wound dressings offer promising approaches surface reconstruction. Against background our future aim develop an innovative substitute, we investigated behavior two established substitutes, a crosslinked non-crosslinked collagen biomatrix. The products were applied topically on total 18 defects paravertebrally back female Göttingen Minipigs—six control remained untreated. evaluation was carried out planimetrically (wound closure time) histologically (neoepidermal cell number epidermis thickness). Both treatment groups demonstrated significantly faster reepithelialization than controls. histologic examination verified highest epidermal thickness in biomatrix-treated whereas showed higher density. Our data presented positive influence regeneration chosen dermis substitutes even without additional transplantation and, thus, donor site morbidity. Therefore, it can be stated that single biomatrix application might used clinical routine small which needs further setting determine size depths suitable bed. Nevertheless, currently available cannot solely achieve healing equal superior tissue. Thus, overarching development substitute manage reconstruction grafting.